I can’t imagine this popup causing the error. In the HMI you can see, that somehow all connections are interrupted - maybe there is a problem with the network. Probably this message pops up, because this OpconDesktopInfo.vbs script also reads information from the network settings and displays it on the desktop. As you mentioned, you can not restart the TwinCat Runtime, so it would be interesting to know the status of the Runtime - maybe you can take a screenshot with open Taskbar, so that the Twincat runtime icon is to see...
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